PDBe 1dhs

X-ray diffraction
2.2Å resolution

CRYSTAL STRUCTURE OF THE NAD COMPLEX OF HUMAN DEOXYHYPUSINE SYNTHASE

Released:

Function and Biology Details

Reaction catalysed:
(1a) spermidine + NAD(+) = dehydrospermidine + NADH
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Deoxyhypusine synthase Chain: A
Molecule details ›
Chain: A
Length: 361 amino acids
Theoretical weight: 40.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P49366 (Residues: 9-369; Coverage: 98%)
Gene names: DHPS, DS
Sequence domains: Deoxyhypusine synthase
Structure domains: Deoxyhypusine synthase

Ligands and Environments


Cofactor: Ligand NAD 1 x NAD
No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P4212
Unit cell:
a: 108.3Å b: 108.3Å c: 69.5Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.153 0.153 0.242
Expression system: Escherichia coli BL21(DE3)