› 1dfv

X-ray diffraction
2.6Å resolution

CRYSTAL STRUCTURE OF HUMAN NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN MONOMER

Released:
DOI: 10.2210/pdb1dfv/pdb
PDB entry 1dfv coloured by chain, front view.
PDB entry 1dfv coloured by chain, side view.
PDB entry 1dfv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Ligand preference inferred from the structure of neutrophil gelatinase associated lipocalin.
Goetz DH, Willie ST, Armen RS, Bratt T, Borregaard N, Strong RK
Biochemistry 39 1935-41 (2000)
PMID: 10684642

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160358 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Neutrophil gelatinase-associated lipocalin Chains: A, B
Molecule details ›
Chains: A, B
Length: 177 amino acids
Theoretical weight: 20.52 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: P80188 (Residues: 21-197; Coverage: 99%)
Gene names: HNL, LCN2, NGAL
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand SO4 3 x SO4
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P41212
Unit cell:
a: 115.021Å b: 115.021Å c: 117.638Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.281 0.281 0.293
Expression system: unidentified baculovirus

Quick links

Citations

32 review citations

Enterobactin: an archetype for microbial iron transport.
Raymond et al. (2003)
31 more

6 mentions without citation

Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex.
Bao et al. (2010)
5 more