1d0g

X-ray diffraction
2.4Å resolution

CRYSTAL STRUCTURE OF DEATH RECEPTOR 5 (DR5) BOUND TO APO2L/TRAIL

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tumor necrosis factor receptor superfamily member 10B Chains: R, S, T
Molecule details ›
Chains: R, S, T
Length: 130 amino acids
Theoretical weight: 14.58 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: O14763 (Residues: 54-183; Coverage: 33%)
Gene names: DR5, KILLER, TNFRSF10B, TRAILR2, TRICK2, UNQ160/PRO186, ZTNFR9
Sequence domains: TNFR/NGFR cysteine-rich region
Structure domains: Tumor Necrosis Factor Receptor, subunit A, domain 2
Tumor necrosis factor ligand superfamily member 10 Chains: A, B, D
Molecule details ›
Chains: A, B, D
Length: 168 amino acids
Theoretical weight: 19.52 KDa
Source organism: Homo sapiens
Expression system: Bacteria
UniProt:
  • Canonical: P50591 (Residues: 114-281; Coverage: 60%)
Gene names: APO2L, TNFSF10, TRAIL
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P212121
Unit cell:
a: 66.818Å b: 111.019Å c: 130.807Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.222 0.267
Expression systems:
  • unidentified baculovirus
  • Bacteria