› 1cx8

X-ray diffraction
3.2Å resolution

CRYSTAL STRUCTURE OF THE ECTODOMAIN OF HUMAN TRANSFERRIN RECEPTOR

Released:
DOI: 10.2210/pdb1cx8/pdb
PDB 1cx8 coloured by chain and viewed from the front.
PDB 1cx8 coloured by chain and viewed from the side.
PDB 1cx8 coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the ectodomain of human transferrin receptor.
Lawrence CM, Ray S, Babyonyshev M, Galluser R, Borhani DW, Harrison SC
Science 286 779-82 (1999)
PMID: 10531064

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transferrin receptor protein 1, serum form Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 639 amino acids
Theoretical weight: 71.62 KDa
Source organism: Homo sapiens
Expression system: Cricetinae gen. sp.
UniProt:
  • Canonical: P02786 (Residues: 122-760; Coverage: 84%)
Gene name: TFRC
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand NAG 24 x NAG
Ligand SM 24 x SM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P212121
Unit cell:
a: 105.4Å b: 216.9Å c: 361.9Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.243 0.243 0.284
Expression system: Cricetinae gen. sp.

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Citations

37 review citations

Engineering antibody and protein therapeutics to cross the blood-brain barrier.
Zhao et al. (2022)
36 more

32 mentions without citation

Structural and Chemical Biology of Presenilin Complexes.
Johnson et al. (2017)
31 more