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THE X-RAY STRUCTURE OF (MEBM2T)1-CYCLOSPORIN COMPLEXED WITH CYCLOPHILIN A PROVIDES AN EXPLANATION FOR ITS ANOMALOUSLY HIGH IMMUNOSUPPRESSIVE ACTIVITY

X-ray diffraction
2.2Å resolution
PDB entry 1cwb coloured by chain, front view.
PDB entry 1cwb coloured by chain, side view.
PDB entry 1cwb coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Peptidyl-prolyl cis-trans isomerase A and peptide
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Multimeric state: hetero dimer
Accessible surface area: 7840.47 Å2
Buried surface area: 1021.7 Å2
Dissociation area: 510.85 Å2
Dissociation energy (ΔGdiss): 2.62 kcal/mol
Dissociation entropy (TΔSdiss): 7.14 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-238754

Macromolecules

Peptidyl-prolyl cis-trans isomerase A
Chain: A
Length: 165 amino acids
Theoretical weight: 18.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62937 (Residues: 1-165; Coverage: 100%)
Gene names: CYPA, PPIA
Pfam: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
InterPro:
CATH: Cyclophilin-like
SCOP: Cyclophilin (peptidylprolyl isomerase)
Peptidyl-prolyl cis-trans isomerase A in PDB entry 1cwb, assembly 1, front view.
Peptidyl-prolyl cis-trans isomerase A in PDB entry 1cwb, assembly 1, side view.
Peptidyl-prolyl cis-trans isomerase A in PDB entry 1cwb, assembly 1, top view.
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CYCLOSPORIN A
Chain: C
Length: 11 amino acids
Theoretical weight: 1.23 KDa
Source organism: Tolypocladium inflatum
Expression system: Not provided
CYCLOSPORIN A in PDB entry 1cwb, assembly 1, front view.
CYCLOSPORIN A in PDB entry 1cwb, assembly 1, side view.
CYCLOSPORIN A in PDB entry 1cwb, assembly 1, top view.
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