› 1co7

X-ray diffraction
1.9Å resolution

R117H mutant rat anionic trypsin complexed with bovine pancreatic trypsin inhibitor (BPTI)

Released:
DOI: 10.2210/pdb1co7/pdb
PDB entry 1co7 coloured by chain, front view.
PDB entry 1co7 coloured by chain, side view.
PDB entry 1co7 coloured by chain, top view.
Source organisms:
Entry authors: Stamper GF, Ringe D, Hedstrom L

Function and Biology Details

Reaction catalysed: 
Preferential cleavage: Arg-|-, Lys-|-.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133397 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Anionic trypsin-2 Chain: E
Molecule details ›
Chain: E
Length: 245 amino acids
Theoretical weight: 26.1 KDa
Source organism: Rattus norvegicus
UniProt:
  • Canonical: P00763 (Residues: 2-246; Coverage: 100%)
Gene names: Prss2, Try2
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Pancreatic trypsin inhibitor Chain: I
Molecule details ›
Chain: I
Length: 99 amino acids
Theoretical weight: 10.78 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00974 (Residues: 2-100; Coverage: 100%)
Sequence domains: Kunitz/Bovine pancreatic trypsin inhibitor domain
Structure domains: Pancreatic trypsin inhibitor Kunitz domain

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P3221
Unit cell:
a: 92.696Å b: 92.696Å c: 62.406Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.208 0.208 0.21

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