1cd9

X-ray diffraction
2.8Å resolution

2:2 COMPLEX OF G-CSF WITH ITS RECEPTOR

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
Non-polymer only tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Granulocyte colony-stimulating factor Chains: A, C
Molecule details ›
Chains: A, C
Length: 175 amino acids
Theoretical weight: 18.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09919 (Residues: 31-207; Coverage: 98%)
  • Best match: P09919-2 (Residues: 31-204)
Gene names: C17orf33, CSF3, GCSF
Sequence domains: Granulocyte colony-stimulating factor
Structure domains: Growth Hormone; Chain: A;
Granulocyte colony-stimulating factor receptor Chains: B, D
Molecule details ›
Chains: B, D
Length: 215 amino acids
Theoretical weight: 24.46 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P40223 (Residues: 120-334; Coverage: 27%)
Gene names: Csf3r, Csfgr
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: I4122
Unit cell:
a: 125.467Å b: 125.467Å c: 372.771Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.237 0.237 0.319
Expression systems:
  • Escherichia coli
  • Spodoptera frugiperda