1c5m

X-ray diffraction
1.95Å resolution

STRUCTURAL BASIS FOR SELECTIVITY OF A SMALL MOLECULE, S1-BINDING, SUB-MICROMOLAR INHIBITOR OF UROKINASE TYPE PLASMINOGEN ACTIVATOR

Released:

Function and Biology Details

Reaction catalysed:
Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Activated factor Xa heavy chain Chain: D
Molecule details ›
Chain: D
Length: 255 amino acids
Theoretical weight: 28.65 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00742 (Residues: 235-480, 481-488; Coverage: 56%)
Gene name: F10
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Factor X light chain Chain: F
Molecule details ›
Chain: F
Length: 96 amino acids
Theoretical weight: 10.53 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00742 (Residues: 84-179; Coverage: 21%)
Gene name: F10
Sequence domains:
Structure domains: Laminin

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P3121
Unit cell:
a: 81.82Å b: 81.82Å c: 108.79Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.218 0.218 0.307