1c3r

X-ray diffraction
2Å resolution

CRYSTAL STRUCTURE OF AN HDAC HOMOLOG COMPLEXED WITH TRICHOSTATIN A

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acetoin utilization protein AcuC Chains: A, B
Molecule details ›
Chains: A, B
Length: 375 amino acids
Theoretical weight: 42.7 KDa
Source organism: Aquifex aeolicus
Expression system: Escherichia coli
UniProt:
  • Canonical: O67135 (Residues: 1-375; Coverage: 100%)
Gene names: acuC1, aq_1023
Sequence domains: Histone deacetylase domain
Structure domains: Histone deacetylase domain

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 53.4Å b: 94.4Å c: 156.3Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.224 0.224 0.258
Expression system: Escherichia coli