1c1a

X-ray diffraction
3.1Å resolution

CRYSTAL STRUCTURE OF RSV TWO-DOMAIN INTEGRASE

Released:
Source organism: Rous sarcoma virus

Function and Biology Details

Reactions catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Endonucleolytic cleavage to 5'-phosphomonoester.
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Integrase Chains: A, B
Molecule details ›
Chains: A, B
Length: 238 amino acids
Theoretical weight: 26.6 KDa
Source organism: Rous sarcoma virus
Expression system: Escherichia coli
UniProt:
  • Canonical: P03354 (Residues: 1329-1566; Coverage: 15%)
Gene name: gag-pol
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9B
Spacegroup: P21
Unit cell:
a: 66.24Å b: 46.339Å c: 94.309Å
α: 90° β: 101.76° γ: 90°
R-values:
R R work R free
0.256 0.256 0.337
Expression system: Escherichia coli