› 1byn

Solution NMR

SOLUTION STRUCTURE OF THE CALCIUM-BOUND FIRST C2-DOMAIN OF SYNAPTOTAGMIN I

Released:
DOI: 10.2210/pdb1byn/pdb
PDB entry 1byn coloured by chain, ensemble of 20 models, front view.
PDB entry 1byn coloured by chain, ensemble of 20 models, side view.
PDB entry 1byn coloured by chain, ensemble of 20 models, top view.
Source organism: Rattus norvegicus
Primary publication:
Solution structures of the Ca2+-free and Ca2+-bound C2A domain of synaptotagmin I: does Ca2+ induce a conformational change?
Shao X, Fernandez I, Südhof TC, Rizo J
Biochemistry 37 16106-15 (1998)
PMID: 9819203

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149380 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Synaptotagmin-1 Chain: A
Molecule details ›
Chain: A
Length: 128 amino acids
Theoretical weight: 14.78 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P21707 (Residues: 140-267; Coverage: 30%)
Gene name: Syt1
Sequence domains: C2 domain
Structure domains: C2 domain

Ligands and Environments

1 bound ligand:
Ligand CA 3 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

26 review citations

How does synaptotagmin trigger neurotransmitter release?
Chapman ER. (2008)
25 more

52 mentions without citation

Phosphatidylserine targeting for diagnosis and treatment of human diseases.
Schutters et al. (2010)
51 more