› 1by1

Solution NMR

DBL homology domain from beta-PIX

Released:
DOI: 10.2210/pdb1by1/pdb
PDB entry 1by1 coloured by chain, ensemble of 20 models, front view.
PDB entry 1by1 coloured by chain, ensemble of 20 models, side view.
PDB entry 1by1 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure and mutagenesis of the Dbl homology domain.
Aghazadeh B, Zhu K, Kubiseski TJ, Liu GA, Pawson T, Zheng Y, Rosen MK
Nat Struct Biol 5 1098-107 (1998)
PMID: 9846881

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171943 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Rho guanine nucleotide exchange factor 7 Chain: A
Molecule details ›
Chain: A
Length: 209 amino acids
Theoretical weight: 23.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q14155 (Residues: 260-467; Coverage: 26%)
Gene names: ARHGEF7, COOL1, KIAA0142, Nbla10314, P85SPR, PAK3BP, PIXB
Sequence domains: RhoGEF domain
Structure domains: Dbl homology (DH) domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: SIMULATED ANNEALING, TORSION ANGLE DYNAMICS
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

12 review citations

GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors.
Rossman et al. (2005)
11 more

7 mentions without citation

The Evolutionary Landscape of Dbl-Like RhoGEF Families: Adapting Eukaryotic Cells to Environmental Signals.
Fort et al. (2017)
6 more