Structure analysis

PH DOMAIN AND BTK MOTIF FROM BRUTON'S TYROSINE KINASE MUTANT E41K IN COMPLEX WITH INS(1,3,4,5)P4

X-ray diffraction
2.1Å resolution
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo tetramer
Accessible surface area: 33900 Å2
Buried surface area: 10500 Å2
Dissociation area: 3,400 Å2
Dissociation energy (ΔGdiss): 3 kcal/mol
Dissociation entropy (TΔSdiss): 38 kcal/mol
Interface energy (ΔGint): -37 kcal/mol
Symmetry number: 2
Assembly 2
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Multimeric state: homo tetramer
Accessible surface area: 31900 Å2
Buried surface area: 12200 Å2
Dissociation area: 2,000 Å2
Dissociation energy (ΔGdiss): 11 kcal/mol
Dissociation entropy (TΔSdiss): 14 kcal/mol
Interface energy (ΔGint): -44 kcal/mol
Symmetry number: 4

Macromolecules

Chains: A, B
Length: 169 amino acids
Theoretical weight: 19.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q06187 (Residues: 2-170; Coverage: 26%)
Gene names: AGMX1, ATK, BPK, BTK
Pfam:
InterPro:
CATH: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
SCOP: Pleckstrin-homology domain (PH domain)

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