› 1bud

X-ray diffraction
1.9Å resolution

ACUTOLYSIN A FROM SNAKE VENOM OF AGKISTRODON ACUTUS AT PH 5.0

Released:
DOI: 10.2210/pdb1bud/pdb
PDB entry 1bud coloured by chain, front view.
PDB entry 1bud coloured by chain, side view.
PDB entry 1bud coloured by chain, top view.
Source organism: Deinagkistrodon acutus
Primary publication:
Crystal structures of acutolysin A, a three-disulfide hemorrhagic zinc metalloproteinase from the snake venom of Agkistrodon acutus.
Gong W, Zhu X, Liu S, Teng M, Niu L
J Mol Biol 283 657-68 (1998)
PMID: 9784374

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192948 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Snake venom metalloproteinase acutolysin-A Chain: A
Molecule details ›
Chain: A
Length: 197 amino acids
Theoretical weight: 21.87 KDa
Source organism: Deinagkistrodon acutus
UniProt:
  • Canonical: Q9PW35 (Residues: 191-388; Coverage: 50%)
Sequence domains: Reprolysin (M12B) family zinc metalloprotease
Structure domains: Collagenase (Catalytic Domain)

Ligands and Environments

2 bound ligands:
Ligand ZN 1 x ZN
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: OTHER
Spacegroup: P43212
Unit cell:
a: 63.47Å b: 63.47Å c: 95.49Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.169 0.169 not available

Quick links

Citations

12 review citations

Structural considerations of the snake venom metalloproteinases, key members of the M12 reprolysin family of metalloproteinases.
Fox et al. (2005)
11 more

4 mentions without citation

ADAM and ADAMTS Family Proteins and Snake Venom Metalloproteinases: A Structural Overview.
Takeda S. (2016)
3 more