› 1btg

X-ray diffraction
2.5Å resolution

CRYSTAL STRUCTURE OF BETA NERVE GROWTH FACTOR AT 2.5 A RESOLUTION IN C2 SPACE GROUP WITH ZN IONS BOUND

Released:
DOI: 10.2210/pdb1btg/pdb
PDB 1btg coloured by chain and viewed from the front.
PDB 1btg coloured by chain and viewed from the side.
PDB 1btg coloured by chain and viewed from the top.
Source organism: Mus musculus
Primary publication:
Nerve growth factor in different crystal forms displays structural flexibility and reveals zinc binding sites.
Holland DR, Cousens LS, Meng W, Matthews BW
J. Mol. Biol. 239 385-400 (1994)
PMID: 8201620

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo trimer
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-nerve growth factor Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 110 amino acids
Theoretical weight: 12.38 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: P01139 (Residues: 130-239; Coverage: 49%)
Gene names: Ngf, Ngfb
Sequence domains: Nerve growth factor family
Structure domains: Cystine-knot cytokines

Ligands and Environments

1 bound ligand:
Ligand ZN 3 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: C2
Unit cell:
a: 109.8Å b: 93.9Å c: 58.9Å
α: 90° β: 123.1° γ: 90°
R-values:
R R work R free
0.179 not available not available
Expression system: Not provided

Quick links

Citations

5 review citations

Structural, biological, and pharmacological strategies for the inhibition of nerve growth factor.
Eibl et al. (2012)
4 more

12 mentions without citation

The nerve of ovulation-inducing factor in semen.
Ratto et al. (2012)
11 more