Structure analysis

STRUCTURE OF THE BRAIN-DERIVED NEUROTROPHIC FACTOR(SLASH)NEUROTROPHIN 3 HETERODIMER

X-ray diffraction
2.3Å resolution
Source organism: Homo sapiens
Assemblies composition:
hetero tetramer
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1
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Multimeric state: hetero tetramer
Accessible surface area: 23600 Å2
Buried surface area: 7700 Å2
Dissociation area: 650 Å2
Dissociation energy (ΔGdiss): -6 kcal/mol
Dissociation entropy (TΔSdiss): 13 kcal/mol
Interface energy (ΔGint): -33 kcal/mol
Symmetry number: 2
Assembly 2 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 12400 Å2
Buried surface area: 3200 Å2
Dissociation area: 1,500 Å2
Dissociation energy (ΔGdiss): 13 kcal/mol
Dissociation entropy (TΔSdiss): 12 kcal/mol
Interface energy (ΔGint): -13 kcal/mol
Symmetry number: 1

Macromolecules

Chain: A
Length: 119 amino acids
Theoretical weight: 13.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P23560 (Residues: 129-247; Coverage: 52%)
Gene name: BDNF
Pfam: Nerve growth factor family
InterPro:
CATH: Cystine-knot cytokines
SCOP: Neurotrophin

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Chain: B
Length: 119 amino acids
Theoretical weight: 13.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P20783 (Residues: 139-257; Coverage: 50%)
Gene name: NTF3
Pfam: Nerve growth factor family
InterPro:
CATH: Cystine-knot cytokines
SCOP: Neurotrophin

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