› 1bke

X-ray diffraction
3.15Å resolution

HUMAN SERUM ALBUMIN IN A COMPLEX WITH MYRISTIC ACID AND TRI-IODOBENZOIC ACID

Released:
DOI: 10.2210/pdb1bke/pdb
PDB 1bke coloured by chain and viewed from the front.
PDB 1bke coloured by chain and viewed from the side.
PDB 1bke coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites.
Curry S, Mandelkow H, Brick P, Franks N
Nat. Struct. Biol. 5 827-35 (1998)
PMID: 9731778

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Albumin Chain: A
Molecule details ›
Chain: A
Length: 581 amino acids
Theoretical weight: 66.13 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P02768 (Residues: 28-608; Coverage: 98%)
Gene names: ALB, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341
Sequence domains: Serum albumin family
Structure domains: Serum Albumin; Chain A, Domain 1

Ligands and Environments

2 bound ligands:
Ligand MYR 5 x MYR
Ligand B3I 2 x B3I
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELLIOTT GX-21
Spacegroup: C2
Unit cell:
a: 187.65Å b: 38.87Å c: 95.91Å
α: 90° β: 105.49° γ: 90°
R-values:
R R work R free
0.177 0.177 0.248
Expression system: Saccharomyces cerevisiae

Quick links

Citations

66 review citations

Albumin-based cancer therapeutics for intraperitoneal drug delivery: a review.
Van de Sande et al. (2020)
65 more

3 mentions without citation

Modeling kinetics of subcellular disposition of chemicals.
Balaz S. (2009)
2 more