Function and Biology Details
Reaction catalysed:
ATP-dependent breakage, passage and rejoining of double-stranded DNA
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
- DNA topoisomerase II, eukaryotic-type
- DNA topoisomerase, type IIA, domain A
- TOPRIM domain
- DNA topoisomerase, type IIA, alpha-helical domain superfamily
- DNA topoisomerase, type IIA, domain A, alpha-beta
- C-terminal associated domain of TOPRIM
- DNA topoisomerase, type IIA, conserved site
- DNA topoisomerase 2, TOPRIM domain
3 more domains
Structure domain:
Structure analysis Details
Assembly composition:
homo dimer (preferred)
Assembly name:
DNA topoisomerase 2 (preferred)
PDBe Complex ID:
PDB-CPX-139226 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA topoisomerase 2
Molecule details ›
P06786Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
NSLS BEAMLINE X4A
Spacegroup:
C2221
Expression system: Saccharomyces cerevisiae
