› 1bei

Solution NMR

Shk-dnp22: A Potent Kv1.3-specific immunosuppressive polypeptide, NMR, 20 structures

Released:
DOI: 10.2210/pdb1bei/pdb
PDB entry 1bei coloured by chain, ensemble of 20 models, front view.
PDB entry 1bei coloured by chain, ensemble of 20 models, side view.
PDB entry 1bei coloured by chain, ensemble of 20 models, top view.
Source organism: Stichodactyla helianthus
Primary publication:
ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide.
Kalman K, Pennington MW, Lanigan MD, Nguyen A, Rauer H, Mahnir V, Paschetto K, Kem WR, Grissmer S, Gutman GA, Christian EP, Cahalan MD, Norton RS, Chandy KG
J Biol Chem 273 32697-707 (1998)
PMID: 9830012

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151364 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kappa-stichotoxin-She3a Chain: A
Molecule details ›
Chain: A
Length: 35 amino acids
Theoretical weight: 4.03 KDa
Source organism: Stichodactyla helianthus
Expression system: Not provided
UniProt:
  • Canonical: P29187 (Residues: 1-35; Coverage: 100%)

Ligands and Environments

No bound ligands
1 modified residue:
Ligand DNP 1 x DNP

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry
Expression system: Not provided

Quick links

Citations

51 review citations

Therapeutic potential of venom peptides.
Lewis et al. (2003)
50 more

1 mention without citation

Computational Insights of the Interaction among Sea Anemones Neurotoxins and Kv1.3 Channel.
Sabogal-Arango et al. (2014)