Structure analysis

THE STRUCTURE OF RESIDUES 7-16 OF THE A ALPHA CHAIN OF HUMAN FIBRINOGEN BOUND TO BOVINE THROMBIN AT 2.3 ANGSTROMS RESOLUTION

X-ray diffraction
2.3Å resolution
Source organisms:
Assemblies composition:
hetero tetramer (preferred)
hetero trimer
hetero hexamer
Entry contents: 5 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 13300 Å2
Buried surface area: 11500 Å2
Dissociation area: 750 Å2
Dissociation energy (ΔGdiss): 6 kcal/mol
Dissociation entropy (TΔSdiss): 7 kcal/mol
Interface energy (ΔGint): -54 kcal/mol
Symmetry number: 1
Assembly 2
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Multimeric state: hetero trimer

Binding statistics and energies are not available for this assembly
Assembly 3
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Multimeric state: hetero trimer
Accessible surface area: 13700 Å2
Buried surface area: 4100 Å2
Dissociation area: 1,300 Å2
Dissociation energy (ΔGdiss): 16 kcal/mol
Dissociation entropy (TΔSdiss): 10 kcal/mol
Interface energy (ΔGint): -16 kcal/mol
Symmetry number: 1
Assembly 4
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Multimeric state: hetero hexamer

Binding statistics and energies are not available for this assembly

Macromolecules

Chains: J, L, M
Length: 49 amino acids
Theoretical weight: 5.74 KDa
Source organism: Bos taurus
Expression system: Not provided
UniProt:
  • Canonical: P00735 (Residues: 318-366; Coverage: 8%)
Gene name: F2
Pfam: Thrombin light chain
InterPro:
SCOP: Eukaryotic proteases

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Chain: H
Length: 150 amino acids
Theoretical weight: 17.53 KDa
Source organism: Bos taurus
Expression system: Not provided
UniProt:
  • Canonical: P00735 (Residues: 367-516; Coverage: 25%)
Gene name: F2
InterPro:
CATH: Trypsin-like serine proteases
SCOP: Eukaryotic proteases

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Chain: E
Length: 109 amino acids
Theoretical weight: 12.27 KDa
Source organism: Bos taurus
Expression system: Not provided
UniProt:
  • Canonical: P00735 (Residues: 517-625; Coverage: 18%)
Gene name: F2
InterPro:
CATH: Trypsin-like serine proteases
SCOP: Eukaryotic proteases

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Chains: F, G, I
Length: 11 amino acids
Theoretical weight: 1.05 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P02671 (Residues: 26-35; Coverage: 1%)
Gene name: FGA

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Chains: K, N
Length: 259 amino acids
Theoretical weight: 29.77 KDa
Source organism: Bos taurus
Expression system: Not provided
UniProt:
  • Canonical: P00735 (Residues: 367-625; Coverage: 43%)
Gene name: F2
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
SCOP: Eukaryotic proteases

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