› 1b4q

Solution NMR

Solution structure of human thioltransferase complex with glutathione

Released:
DOI: 10.2210/pdb1b4q/pdb
PDB entry 1b4q coloured by chain, ensemble of 21 models, front view.
PDB entry 1b4q coloured by chain, ensemble of 21 models, side view.
PDB entry 1b4q coloured by chain, ensemble of 21 models, top view.
Source organism: Homo sapiens
Primary publication:
Reactivity of the human thioltransferase (glutaredoxin) C7S, C25S, C78S, C82S mutant and NMR solution structure of its glutathionyl mixed disulfide intermediate reflect catalytic specificity.
Yang Y, Jao Sc, Nanduri S, Starke DW, Mieyal JJ, Qin J
Biochemistry 37 17145-56 (1998)
PMID: 9860827

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153015 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutaredoxin-1 Chain: A
Molecule details ›
Chain: A
Length: 105 amino acids
Theoretical weight: 11.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35754 (Residues: 2-106; Coverage: 99%)
Gene names: GLRX, GRX
Sequence domains: Glutaredoxin
Structure domains: Glutaredoxin

Ligands and Environments

1 bound ligand:
Ligand GSH 1 x GSH
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

19 review citations

Thioredoxin and related molecules--from biology to health and disease.
Lillig et al. (2007)
18 more

11 mentions without citation

Glutaredoxin: Discovery, redox defense and much more.
Ogata et al. (2021)
10 more