Function and Biology

HUMAN ACETYLCHOLINESTERASE COMPLEXED WITH FASCICULIN-II, GLYCOSYLATED PROTEIN

Source organisms:
Biochemical function: toxin activity
Biological process: modulation of process of another organism
Cellular component: extracellular region

EC 3.1.1.7: Acetylcholinesterase

Reaction catalysed:
Acetylcholine + H(2)O = choline + acetate
Systematic name:
Acetylcholine acetylhydrolase
Alternative Name(s):
  • AcCholE
  • Acetyl.beta-methylcholinesterase
  • Acetylcholine hydrolase
  • Acetylthiocholinesterase
  • Choline esterase I
  • Cholinesterase
  • True cholinesterase

Sequence family

Pfam Protein family (Pfam)
PF00135
Domain description: Carboxylesterase family
Occurring in:
  1. Acetylcholinesterase
The deposited structure of PDB entry 1b41 contains 1 copy of Pfam domain PF00135 (Carboxylesterase family) in Acetylcholinesterase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000997
Domain description: Cholinesterase
Occurring in:
  1. Acetylcholinesterase
IPR045860
Domain description: Snake toxin-like superfamily
Occurring in:
  1. Fasciculin-2
IPR029058
Domain description: Alpha/Beta hydrolase fold
Occurring in:
  1. Acetylcholinesterase
IPR018354
Domain description: Snake toxin, conserved site
Occurring in:
  1. Fasciculin-2
IPR003571
Domain description: Snake three-finger toxin
Occurring in:
  1. Fasciculin-2
IPR019826
Domain description: Carboxylesterase type B, active site
Occurring in:
  1. Acetylcholinesterase
IPR019819
Domain description: Carboxylesterase type B, conserved site
Occurring in:
  1. Acetylcholinesterase
IPR002018
Domain description: Carboxylesterase, type B
Occurring in:
  1. Acetylcholinesterase

Structure domains

CATH CATH domains
2.10.60.10
Class: Mainly Beta
Architecture: Ribbon
Topology: CD59
Homology: CD59
Occurring in:
  1. Fasciculin-2
The deposited structure of PDB entry 1b41 contains 1 copy of CATH domain 2.10.60.10 (CD59) in Fasciculin-2. Showing 1 copy in chain B.
3.40.50.1820
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: alpha/beta hydrolase
Occurring in:
  1. Acetylcholinesterase
The deposited structure of PDB entry 1b41 contains 1 copy of CATH domain 3.40.50.1820 (Rossmann fold) in Acetylcholinesterase. Showing 1 copy in chain A.
SCOP SCOP annotations
57303
Class: Small proteins
Fold: Snake toxin-like
Superfamily: Snake toxin-like
Occurring in:
  1. Fasciculin-2
The deposited structure of PDB entry 1b41 contains 1 copy of SCOP domain 57303 (Snake venom toxins) in Fasciculin-2. Showing 1 copy in chain B.
53475
Class: Alpha and beta proteins (a/b)
Fold: alpha/beta-Hydrolases
Superfamily: alpha/beta-Hydrolases
Occurring in:
  1. Acetylcholinesterase
The deposited structure of PDB entry 1b41 contains 1 copy of SCOP domain 53475 (Acetylcholinesterase-like) in Acetylcholinesterase. Showing 1 copy in chain A.