X-ray diffraction
2.4Å resolution

Human obesity protein, leptin


Function and Biology Details

Biochemical function:
Cellular component:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo trimer
Entry contents:
1 distinct polypeptide molecule
Leptin Chain: A
Molecule details ›
Chain: A
Length: 146 amino acids
Theoretical weight: 15.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P41159 (Residues: 22-167; Coverage: 100%)
Gene names: LEP, OB, OBS
Sequence domains: Leptin
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P63
Unit cell:
a: 88.14Å b: 88.14Å c: 48.05Å
α: 90° β: 90° γ: 120°
R R work R free
0.185 0.185 0.283
Expression system: Escherichia coli BL21(DE3)