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MOUSE GABP ALPHA/BETA DOMAIN BOUND TO DNA

X-ray diffraction
2.15Å resolution
PDB entry 1awc coloured by chain, front view.
PDB entry 1awc coloured by chain, side view.
PDB entry 1awc coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: GA-binding protein and DNA
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Multimeric state: hetero tetramer
Accessible surface area: 17410.76 Å2
Buried surface area: 8287.86 Å2
Dissociation area: 866.81 Å2
Dissociation energy (ΔGdiss): 4.97 kcal/mol
Dissociation entropy (TΔSdiss): 12.17 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-113443

Macromolecules

GA-binding protein alpha chain
Chain: A
Length: 110 amino acids
Theoretical weight: 13.07 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q00422 (Residues: 320-429; Coverage: 24%)
Gene names: E4tf1a, Gabpa
Pfam: Ets-domain
InterPro:
CATH: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
SCOP: ets domain
GA-binding protein alpha chain in PDB entry 1awc, assembly 1, front view.
GA-binding protein alpha chain in PDB entry 1awc, assembly 1, side view.
GA-binding protein alpha chain in PDB entry 1awc, assembly 1, top view.
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GA-binding protein subunit beta-1
Chain: B
Length: 153 amino acids
Theoretical weight: 16.83 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q00420 (Residues: 5-157; Coverage: 40%)
Gene names: Gabpb, Gabpb1, Gabpb2
Pfam:
InterPro:
CATH: Ankyrin repeat-containing domain
SCOP: Ankyrin repeat
GA-binding protein subunit beta-1 in PDB entry 1awc, assembly 1, front view.
GA-binding protein subunit beta-1 in PDB entry 1awc, assembly 1, side view.
GA-binding protein subunit beta-1 in PDB entry 1awc, assembly 1, top view.
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DNA chain D
Name: DNA (5'-D(*AP*AP*(BRU)P*GP*AP*CP*CP*GP*GP*AP*AP*GP*TP*AP*(CBR)P*AP*CP*(CBR)P*GP*GP*A)-3')
Representative chains: D
Length: 21 nucleotides
Theoretical weight: 6.71 KDa
DNA (5'-D(*AP*AP*(BRU)P*GP*AP*CP*CP*GP*GP*AP*AP*GP*TP*AP*(CBR)P*AP*CP*(CBR)P*GP*GP*A)-3') in PDB entry 1awc, assembly 1, front view.
DNA (5'-D(*AP*AP*(BRU)P*GP*AP*CP*CP*GP*GP*AP*AP*GP*TP*AP*(CBR)P*AP*CP*(CBR)P*GP*GP*A)-3') in PDB entry 1awc, assembly 1, side view.
DNA (5'-D(*AP*AP*(BRU)P*GP*AP*CP*CP*GP*GP*AP*AP*GP*TP*AP*(CBR)P*AP*CP*(CBR)P*GP*GP*A)-3') in PDB entry 1awc, assembly 1, top view.
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DNA chain E
Name: DNA (5'-D(*TP*TP*CP*CP*GP*GP*(BRU)P*GP*(BRU)P*AP*CP*TP*TP*CP*CP*GP*GP*TP*CP*AP*T)-3')
Representative chains: E
Length: 21 nucleotides
Theoretical weight: 6.53 KDa
DNA (5'-D(*TP*TP*CP*CP*GP*GP*(BRU)P*GP*(BRU)P*AP*CP*TP*TP*CP*CP*GP*GP*TP*CP*AP*T)-3') in PDB entry 1awc, assembly 1, front view.
DNA (5'-D(*TP*TP*CP*CP*GP*GP*(BRU)P*GP*(BRU)P*AP*CP*TP*TP*CP*CP*GP*GP*TP*CP*AP*T)-3') in PDB entry 1awc, assembly 1, side view.
DNA (5'-D(*TP*TP*CP*CP*GP*GP*(BRU)P*GP*(BRU)P*AP*CP*TP*TP*CP*CP*GP*GP*TP*CP*AP*T)-3') in PDB entry 1awc, assembly 1, top view.
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