Structure analysis

THROMBIN INHIBITOR FROM TRIATOMA PALLIDIPENNIS

X-ray diffraction
2.6Å resolution
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 19900 Å2
Buried surface area: 4700 Å2
Dissociation area: 700 Å2
Dissociation energy (ΔGdiss): -3 kcal/mol
Dissociation entropy (TΔSdiss): 12 kcal/mol
Interface energy (ΔGint): -21 kcal/mol
Symmetry number: 1

Macromolecules

Chain: L
Length: 41 amino acids
Theoretical weight: 4.79 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00735 (Residues: 326-366; Coverage: 7%)
Gene name: F2
InterPro:
CATH: Thrombin light chain domain
SCOP: Eukaryotic proteases

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Chain: H
Length: 259 amino acids
Theoretical weight: 29.77 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00735 (Residues: 367-625; Coverage: 43%)
Gene name: F2
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
SCOP: Eukaryotic proteases

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Chain: I
Length: 142 amino acids
Theoretical weight: 16.04 KDa
Source organism: Meccus pallidipennis
Expression system: INSECT CELLS
UniProt:
  • Canonical: Q27049 (Residues: 19-160; Coverage: 100%)
InterPro:
CATH: Lipocalin
SCOP: Thrombin inhibitor

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