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TYR34->PHE MUTANT OF HUMAN MITOCHONDRIAL MANGANESE SUPEROXIDE DISMUTASE

Source organism: Homo sapiens
Biochemical function: metal ion binding
Biological process: superoxide metabolic process
Cellular component: not assigned

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EC 1.15.1.1: Superoxide dismutase

Reaction catalysed:
2 superoxide + 2 H(+) = O(2) + H(2)O(2)
Systematic name:
Superoxide:superoxide oxidoreductase
Alternative Name(s):
  • Copper-zinc superoxide dismutase
  • Cu,Zn-SOD
  • Cu-Zn superoxide dismutase
  • Cuprein
  • Cytocuprein
  • Erythrocuprein
  • Fe-SOD
  • Ferrisuperoxide dismutase
  • Hemocuprein
  • Hepatocuprein
  • Mn-SOD
  • SOD
  • SOD-1
  • SOD-2
  • SOD-3
  • SOD-4
  • SODF
  • SODS
  • Superoxidase dismutase
  • Superoxide dismutase I
  • Superoxide dismutase II

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF02777
Domain description: Iron/manganese superoxide dismutases, C-terminal domain
Occurring in:
  1. Superoxide dismutase [Mn], mitochondrial
The deposited structure of PDB entry 1ap6 contains 2 copies of Pfam domain PF02777 (Iron/manganese superoxide dismutases, C-terminal domain) in Superoxide dismutase [Mn], mitochondrial. Showing 1 copy in chain A.

PF00081
Domain description: Iron/manganese superoxide dismutases, alpha-hairpin domain
Occurring in:
  1. Superoxide dismutase [Mn], mitochondrial
The deposited structure of PDB entry 1ap6 contains 2 copies of Pfam domain PF00081 (Iron/manganese superoxide dismutases, alpha-hairpin domain) in Superoxide dismutase [Mn], mitochondrial. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001189
Domain description: Manganese/iron superoxide dismutase
Occurring in:
  1. Superoxide dismutase [Mn], mitochondrial
IPR036314
Domain description: Manganese/iron superoxide dismutase, C-terminal domain superfamily
Occurring in:
  1. Superoxide dismutase [Mn], mitochondrial
IPR036324
Domain description: Manganese/iron superoxide dismutase, N-terminal domain superfamily
Occurring in:
  1. Superoxide dismutase [Mn], mitochondrial
IPR019833
Domain description: Manganese/iron superoxide dismutase, binding site
Occurring in:
  1. Superoxide dismutase [Mn], mitochondrial
IPR019832
Domain description: Manganese/iron superoxide dismutase, C-terminal
Occurring in:
  1. Superoxide dismutase [Mn], mitochondrial
IPR019831
Domain description: Manganese/iron superoxide dismutase, N-terminal
Occurring in:
  1. Superoxide dismutase [Mn], mitochondrial

Structure domains

CATH CATH domains
3.55.40.20
Class: Alpha Beta
Architecture: 3-Layer(bab) Sandwich
Topology: minor pseudopilin epsh fold
Homology: Iron/manganese superoxide dismutase, C-terminal domain
Occurring in:
  1. Superoxide dismutase [Mn], mitochondrial
The deposited structure of PDB entry 1ap6 contains 2 copies of CATH domain 3.55.40.20 (minor pseudopilin epsh fold) in Superoxide dismutase [Mn], mitochondrial. Showing 1 copy in chain A.
1.10.287.990
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Helix Hairpins
Homology: Fe,Mn superoxide dismutase (SOD) domain
Occurring in:
  1. Superoxide dismutase [Mn], mitochondrial
The deposited structure of PDB entry 1ap6 contains 2 copies of CATH domain 1.10.287.990 (Helix Hairpins) in Superoxide dismutase [Mn], mitochondrial. Showing 1 copy in chain A.
SCOP SCOP annotations
54720
Class: Alpha and beta proteins (a+b)
Fold: Fe,Mn superoxide dismutase (SOD), C-terminal domain
Superfamily: Fe,Mn superoxide dismutase (SOD), C-terminal domain
Occurring in:
  1. Superoxide dismutase [Mn], mitochondrial
The deposited structure of PDB entry 1ap6 contains 2 copies of SCOP domain 54720 (Fe,Mn superoxide dismutase (SOD), C-terminal domain) in Superoxide dismutase [Mn], mitochondrial. Showing 1 copy in chain A.
46610
Class: All alpha proteins
Fold: Long alpha-hairpin
Superfamily: Fe,Mn superoxide dismutase (SOD), N-terminal domain
Occurring in:
  1. Superoxide dismutase [Mn], mitochondrial
The deposited structure of PDB entry 1ap6 contains 2 copies of SCOP domain 46610 (Fe,Mn superoxide dismutase (SOD), N-terminal domain) in Superoxide dismutase [Mn], mitochondrial. Showing 1 copy in chain A.

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