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A SURFACE MUTANT (G82R) OF A HUMAN ALPHA-GLUTATHIONE S-TRANSFERASE SHOWS DECREASED THERMAL STABILITY AND A NEW MODE OF MOLECULAR ASSOCIATION IN THE CRYSTAL

Source organism: synthetic construct
Biochemical function: transferase activity
Biological process: epithelial cell differentiation
Cellular component: extracellular exosome

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EC 2.5.1.18: Glutathione transferase

Reaction catalysed:
RX + glutathione = HX + R-S-glutathione
Systematic name:
RX:glutathione R-transferase
Alternative Name(s):
  • Glutathione S-alkyl transferase
  • Glutathione S-alkyltransferase
  • Glutathione S-aralkyltransferase
  • Glutathione S-aryltransferase
  • Glutathione S-transferase
  • S-(hydroxyalkyl)glutathione lyase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00043
Domain description: Glutathione S-transferase, C-terminal domain
Occurring in:
  1. Glutathione S-transferase A2
The deposited structure of PDB entry 1ags contains 2 copies of Pfam domain PF00043 (Glutathione S-transferase, C-terminal domain) in Glutathione S-transferase A2. Showing 1 copy in chain A.

PF02798
Domain description: Glutathione S-transferase, N-terminal domain
Occurring in:
  1. Glutathione S-transferase A2
The deposited structure of PDB entry 1ags contains 2 copies of Pfam domain PF02798 (Glutathione S-transferase, N-terminal domain) in Glutathione S-transferase A2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003080
Domain description: Glutathione S-transferase, alpha class
Occurring in:
  1. Glutathione S-transferase A2
IPR004045
Domain description: Glutathione S-transferase, N-terminal
Occurring in:
  1. Glutathione S-transferase A2
IPR004046
Domain description: Glutathione S-transferase, C-terminal
Occurring in:
  1. Glutathione S-transferase A2
IPR010987
Domain description: Glutathione S-transferase, C-terminal-like
Occurring in:
  1. Glutathione S-transferase A2
IPR036282
Domain description: Glutathione S-transferase, C-terminal domain superfamily
Occurring in:
  1. Glutathione S-transferase A2
IPR040079
Domain description: Glutathione transferase family
Occurring in:
  1. Glutathione S-transferase A2
IPR036249
Domain description: Thioredoxin-like superfamily
Occurring in:
  1. Glutathione S-transferase A2

Structure domain

SCOP SCOP annotations
47617
Class: All alpha proteins
Fold: GST C-terminal domain-like
Superfamily: GST C-terminal domain-like
Occurring in:
  1. Glutathione S-transferase A2
The deposited structure of PDB entry 1ags contains 2 copies of SCOP domain 47617 (Glutathione S-transferase (GST), C-terminal domain) in Glutathione S-transferase A2. Showing 1 copy in chain A.
52862
Class: Alpha and beta proteins (a/b)
Fold: Thioredoxin fold
Superfamily: Thioredoxin-like
Occurring in:
  1. Glutathione S-transferase A2
The deposited structure of PDB entry 1ags contains 2 copies of SCOP domain 52862 (Glutathione S-transferase (GST), N-terminal domain) in Glutathione S-transferase A2. Showing 1 copy in chain A.

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