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59KDA FRAGMENT OF GYRASE A FROM E. COLI

Source organism: Escherichia coli
Biochemical function: ATP binding
Biological process: DNA topological change
Cellular component: not assigned

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EC 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing)

Reaction catalysed:
ATP-dependent breakage, passage and rejoining of double-stranded DNA
Systematic name:
DNA topoisomerase (ATP-hydrolyzing)
Alternative Name(s):
  • DNA gyrase
  • DNA topoisomerase II
  • Type II DNA topoisomerase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00521
Domain description: DNA gyrase/topoisomerase IV, subunit A
Occurring in:
  1. DNA gyrase subunit A
The deposited structure of PDB entry 1ab4 contains 1 copy of Pfam domain PF00521 (DNA gyrase/topoisomerase IV, subunit A) in DNA gyrase subunit A. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002205
Domain description: DNA topoisomerase, type IIA, domain A
Occurring in:
  1. DNA gyrase subunit A
IPR013757
Domain description: DNA topoisomerase, type IIA, alpha-helical domain superfamily
Occurring in:
  1. DNA gyrase subunit A
IPR013758
Domain description: DNA topoisomerase, type IIA, domain A, alpha-beta
Occurring in:
  1. DNA gyrase subunit A
IPR013760
Domain description: DNA topoisomerase, type IIA-like domain superfamily
Occurring in:
  1. DNA gyrase subunit A

Structure domains

CATH CATH domains
3.90.199.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Topoisomerase II; domain 5
Homology: Topoisomerase II, domain 5
Occurring in:
  1. DNA gyrase subunit A
The deposited structure of PDB entry 1ab4 contains 1 copy of CATH domain 3.90.199.10 (Topoisomerase II; domain 5) in DNA gyrase subunit A. Showing 1 copy in chain A.
1.10.268.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Topoisomerase; domain 3
Homology: Topoisomerase, domain 3
Occurring in:
  1. DNA gyrase subunit A
The deposited structure of PDB entry 1ab4 contains 1 copy of CATH domain 1.10.268.10 (Topoisomerase; domain 3) in DNA gyrase subunit A. Showing 1 copy in chain A.
3.30.1360.40
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Gyrase A; domain 2
Homology: Gyrase A; domain 2
Occurring in:
  1. DNA gyrase subunit A
The deposited structure of PDB entry 1ab4 contains 1 copy of CATH domain 3.30.1360.40 (Gyrase A; domain 2) in DNA gyrase subunit A. Showing 1 copy in chain A.
SCOP SCOP annotation
56720
Class: Multi-domain proteins (alpha and beta)
Fold: Type II DNA topoisomerase
Superfamily: Type II DNA topoisomerase
Occurring in:
  1. DNA gyrase subunit A
The deposited structure of PDB entry 1ab4 contains 1 copy of SCOP domain 56720 (Type II DNA topoisomerase) in DNA gyrase subunit A. Showing 1 copy in chain A.

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