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XPRTASE FROM E. COLI COMPLEXED WITH MG:CPRPP AND GUANINE

Source organism: Escherichia coli
Biochemical function: guanosine tetraphosphate binding
Biological process: protein homotetramerization
Cellular component: protein-containing complex

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EC 2.4.2.22: Xanthine phosphoribosyltransferase

Reaction catalysed:
XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine
Systematic name:
XMP:diphosphate 5-phospho-alpha-D-ribosyltransferase
Alternative Name(s):
  • 5-phospho-alpha-D-ribose-1-diphosphate:xanthine phospho-D-ribosyltransferase
  • XMP pyrophosphorylase
  • Xan phosphoribosyltransferase
  • Xanthine-guanine phosphoribosyltransferase
  • Xanthosine 5'-phosphate pyrophosphorylase
  • Xanthylate pyrophosphorylase
  • Xanthylic pyrophosphorylase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00156
Domain description: Phosphoribosyl transferase domain
Occurring in:
  1. Xanthine-guanine phosphoribosyltransferase
The deposited structure of PDB entry 1a95 contains 4 copies of Pfam domain PF00156 (Phosphoribosyl transferase domain) in Xanthine-guanine phosphoribosyltransferase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR000836
Domain description: Phosphoribosyltransferase domain
Occurring in:
  1. Xanthine-guanine phosphoribosyltransferase
IPR029057
Domain description: Phosphoribosyltransferase-like
Occurring in:
  1. Xanthine-guanine phosphoribosyltransferase
IPR023747
Domain description: Xanthine-guanine phosphoribosyltransferase
Occurring in:
  1. Xanthine-guanine phosphoribosyltransferase

Structure domain

CATH CATH domain
3.40.50.2020
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Xanthine-guanine phosphoribosyltransferase
The deposited structure of PDB entry 1a95 contains 4 copies of CATH domain 3.40.50.2020 (Rossmann fold) in Xanthine-guanine phosphoribosyltransferase. Showing 1 copy in chain B.
SCOP SCOP annotation
53272
Class: Alpha and beta proteins (a/b)
Fold: PRTase-like
Superfamily: PRTase-like
Occurring in:
  1. Xanthine-guanine phosphoribosyltransferase
The deposited structure of PDB entry 1a95 contains 4 copies of SCOP domain 53272 (Phosphoribosyltransferases (PRTases)) in Xanthine-guanine phosphoribosyltransferase. Showing 1 copy in chain B.

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