› 1a78

X-ray diffraction
2Å resolution

COMPLEX OF TOAD OVARY GALECTIN WITH THIO-DIGALACTOSE

Released:
DOI: 10.2210/pdb1a78/pdb
PDB entry 1a78 coloured by chain, front view.
PDB entry 1a78 coloured by chain, side view.
PDB entry 1a78 coloured by chain, top view.
Source organism: Rhinella arenarum
Primary publication:
Soluble beta-galactosyl-binding lectin (galectin) from toad ovary: crystallographic studies of two protein-sugar complexes.
Bianchet MA, Ahmed H, Vasta GR, Amzel LM
Proteins 40 378-88 (2000)
PMID: 10861929

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157433 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Galectin-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 134 amino acids
Theoretical weight: 14.73 KDa
Source organism: Rhinella arenarum
UniProt:
  • Canonical: P56217 (Residues: 1-134; Coverage: 100%)
Sequence domains: Galactoside-binding lectin
Structure domains: Jelly Rolls

Ligands and Environments

Carbohydrate polymer : NEW Components: YIO, GAL
Ligand YIO 2 x YIO
Ligand GAL 2 x GAL
1 bound ligand:
Ligand DTT 1 x DTT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P21
Unit cell:
a: 51.8Å b: 51Å c: 56.3Å
α: 90° β: 97.2° γ: 90°
R-values:
R R work R free
0.194 0.194 0.256

Quick links

Citations

15 review citations

Roles of galectins in infection.
Vasta GR. (2009)
14 more

3 mentions without citation

Insights into the quaternary association of proteins through structure graphs: a case study of lectins.
Brinda et al. (2005)
2 more