1a66

Solution NMR

SOLUTION NMR STRUCTURE OF THE CORE NFATC1/DNA COMPLEX, 18 STRUCTURES

Released:
Source organism: Homo sapiens
Primary publication:
Solution structure of the core NFATC1/DNA complex.
Cell 92 687-96 (1998)
PMID: 9506523

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
Macromolecules (3 distinct):
Nuclear factor of activated T-cells, cytoplasmic 1 Chain: A
Molecule details ›
Chain: A
Length: 178 amino acids
Theoretical weight: 20 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O95644 (Residues: 414-591; Coverage: 19%)
  • Best match: O95644-17 (Residues: 1-119)
Gene names: NFAT2, NFATC, NFATC1
Sequence domains: Rel homology DNA-binding domain
Structure domains: Rel homology domain (RHD), DNA-binding domain
DNA (5'-D(*CP*GP*AP*GP*GP*AP*AP*AP*AP*TP*TP*G)-3') Chain: B
Molecule details ›
Chain: B
Length: 12 nucleotides
Theoretical weight: 3.74 KDa
Source organism: Homo sapiens
Expression system: Not provided
DNA (5'-D(*CP*AP*AP*TP*TP*TP*TP*CP*CP*TP*CP*G)-3') Chain: C
Molecule details ›
Chain: C
Length: 12 nucleotides
Theoretical weight: 3.59 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: TORSION ANGLE DYNAMICS AND SIMULATED ANNEALING
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided