› 1zye

X-ray diffraction
3.3Å resolution

Crystal structure analysis of Bovine Mitochondrial Peroxiredoxin III

Released:
DOI: 10.2210/pdb1zye/pdb
PDB entry 1zye coloured by chain, front view.
PDB entry 1zye coloured by chain, side view.
PDB entry 1zye coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Bovine mitochondrial peroxiredoxin III forms a two-ring catenane.
Cao Z, Roszak AW, Gourlay LJ, Lindsay JG, Isaacs NW
Structure 13 1661-4 (2005)
PMID: 16271889

Function and Biology Details

Reaction catalysed: 
Thioredoxin + ROOH = thioredoxin disulfide + H(2)O + ROH
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo 24-mer
homo dodecamer
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152998 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thioredoxin-dependent peroxide reductase, mitochondrial Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 220 amino acids
Theoretical weight: 24.37 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: P35705 (Residues: 63-257; Coverage: 76%)
Gene names: AOP1, PRDX3
Sequence domains:
Structure domains: Glutaredoxin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: C2
Unit cell:
a: 300.995Å b: 80.679Å c: 124.295Å
α: 90° β: 112.76° γ: 90°
R-values:
R R work R free
0.228 0.226 0.265
Expression system: Escherichia coli

Quick links

Citations

15 review citations

Redox-based regulation of signal transduction: principles, pitfalls, and promises.
Janssen-Heininger et al. (2008)
14 more

10 mentions without citation

Structure-based insights into the catalytic power and conformational dexterity of peroxiredoxins.
Hall et al. (2011)
9 more