X-ray diffraction
2.51Å resolution

Human DNA topoisomerase IIa ATPase/ADP


Function and Biology Details

Reaction catalysed:
ATP-dependent breakage, passage and rejoining of double-stranded DNA
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
DNA topoisomerase 2-alpha Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 400 amino acids
Theoretical weight: 45.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P11388 (Residues: 29-428; Coverage: 26%)
Gene names: TOP2, TOP2A
Sequence domains: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Structure domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21
Unit cell:
a: 71.015Å b: 90.492Å c: 148.293Å
α: 90° β: 89.97° γ: 90°
R R work R free
0.235 0.235 0.281
Expression system: Escherichia coli