1zv8

X-ray diffraction
1.94Å resolution

A structure-based mechanism of SARS virus membrane fusion

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Spike protein S2' Chains: A, C, E, G, I, K
Molecule details ›
Chains: A, C, E, G, I, K
Length: 50 amino acids
Theoretical weight: 5.43 KDa
Source organism: Severe acute respiratory syndrome-related coronavirus
Expression system: Escherichia coli
UniProt:
  • Canonical: P59594 (Residues: 901-950; Coverage: 4%)
Gene names: 2, S
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Spike protein S2' Chains: B, D, F, H, J, L
Molecule details ›
Chains: B, D, F, H, J, L
Length: 36 amino acids
Theoretical weight: 4.01 KDa
Source organism: Severe acute respiratory syndrome-related coronavirus
Expression system: Escherichia coli
UniProt:
  • Canonical: P59594 (Residues: 1150-1185; Coverage: 3%)
Gene names: 2, S

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P1
Unit cell:
a: 31.054Å b: 55.565Å c: 71.678Å
α: 81.26° β: 87.08° γ: 84.1°
R-values:
R R work R free
0.207 0.203 0.274
Expression system: Escherichia coli