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X-ray diffraction
2.3Å resolution

Crystal Structure Of Mycobacterium tuberculosis Guanylate Kinase In Complex With GDP

Released:

Function and Biology Details

Reaction catalysed:
ATP + GMP = ADP + GDP
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Guanylate kinase Chain: A
Molecule details ›
Chain: A
Length: 207 amino acids
Theoretical weight: 21.99 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WKE9 (Residues: 2-208; Coverage: 100%)
Gene names: MTCY21B4.06, Rv1389, gmk
Sequence domains: Guanylate kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: I23
Unit cell:
a: 113.046Å b: 113.046Å c: 113.046Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.184 0.236
Expression system: Escherichia coli