PDBe 1zkl

X-ray diffraction
1.67Å resolution

Multiple Determinants for Inhibitor Selectivity of Cyclic Nucleotide Phosphodiesterases

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A Chain: A
Molecule details ›
Chain: A
Length: 353 amino acids
Theoretical weight: 40.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q13946 (Residues: 130-482; Coverage: 73%)
Gene name: PDE7A
Sequence domains: 3'5'-cyclic nucleotide phosphodiesterase
Structure domains: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P3121
Unit cell:
a: 115.751Å b: 115.751Å c: 64.29Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.194 0.194 0.207
Expression system: Escherichia coli BL21