› 1zkh

Solution NMR

Solution structure of a human ubiquitin-like domain in SF3A1

Released:
DOI: 10.2210/pdb1zkh/pdb
PDB entry 1zkh coloured by chain, ensemble of 20 models, front view.
PDB entry 1zkh coloured by chain, ensemble of 20 models, side view.
PDB entry 1zkh coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Lukin JA, Dhe-Paganon S, Guido V, Lemak A, Avvakumov GV, Xue S, Newman EM, Mackenzie F, Sundstrom M, Edwards A, Arrowsmith CH, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172293 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Splicing factor 3A subunit 1 Chain: A
Molecule details ›
Chain: A
Length: 86 amino acids
Theoretical weight: 9.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15459 (Residues: 704-789; Coverage: 11%)
Gene names: SAP114, SF3A1
Sequence domains: Ubiquitin family
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: 100 structures were calculated by CYANA 2.0 using 2667 NOE-derived distance constraints, 121 dihedral angle constraints, and 50 distance constraints from hydrogen bonds. The 20 structures with lowest target functions were subjected to refinement with CNS 1.1.
Expression system: Escherichia coli

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