PDBe 1z8g

X-ray diffraction
1.55Å resolution

Crystal structure of the extracellular region of the transmembrane serine protease hepsin with covalently bound preferred substrate.

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Serine protease hepsin catalytic chain Chain: A
Molecule details ›
Chain: A
Length: 372 amino acids
Theoretical weight: 40.45 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P05981 (Residues: 46-417; Coverage: 89%)
Gene names: HPN, TMPRSS1
Sequence domains:
Structure domains:
ACE-LYS-GLN-LEU-ARG-Chloromethylketone Chain: L
Molecule details ›
Chain: L
Length: 6 amino acids
Theoretical weight: 606 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P21
Unit cell:
a: 55.705Å b: 47.633Å c: 67.791Å
α: 90° β: 108.24° γ: 90°
R-values:
R R work R free
0.198 0.196 0.217
Expression systems:
  • Komagataella pastoris
  • Not provided