› 1z6t

X-ray diffraction
2.21Å resolution

Structure of the apoptotic protease-activating factor 1 bound to ADP

Released:
DOI: 10.2210/pdb1z6t/pdb
PDB entry 1z6t coloured by chain, front view.
PDB entry 1z6t coloured by chain, side view.
PDB entry 1z6t coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the apoptotic protease-activating factor 1 bound to ADP.
Riedl SJ, Li W, Chao Y, Schwarzenbacher R, Shi Y
Nature 434 926-33 (2005)
PMID: 15829969

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127061 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apoptotic protease-activating factor 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 591 amino acids
Theoretical weight: 67.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O14727 (Residues: 1-591; Coverage: 47%)
Gene names: APAF1, KIAA0413
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ADP 4 x ADP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P1
Unit cell:
a: 75.955Å b: 92.883Å c: 94.988Å
α: 62.96° β: 89.99° γ: 90.05°
R-values:
R R work R free
0.192 0.189 0.244
Expression system: Escherichia coli BL21(DE3)

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Citations

69 review citations

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40 mentions without citation

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