› 1z2v

X-ray diffraction
1.9Å resolution

Crystal Structure of Glu60 deletion Mutant of Human Acidic Fibroblast Growth Factor

Released:
DOI: 10.2210/pdb1z2v/pdb
PDB entry 1z2v coloured by chain, front view.
PDB entry 1z2v coloured by chain, side view.
PDB entry 1z2v coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Conversion of type I 4:6 to 3:5 beta-turn types in human acidic fibroblast growth factor: effects upon structure, stability, folding, and mitogenic function.
Lee J, Dubey VK, Somasundaram T, Blaber M
Proteins 62 686-97 (2006)
PMID: 16355415

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138603 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 145 amino acids
Theoretical weight: 16.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05230 (Residues: 16-155; Coverage: 90%)
Gene names: FGF1, FGFA
Sequence domains: Fibroblast growth factor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

1 bound ligand:
Ligand SO4 4 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: C2221
Unit cell:
a: 73.239Å b: 97.984Å c: 109.269Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.186 0.221
Expression system: Escherichia coli BL21(DE3)

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Citations

1 review citation

Eukaryotic protein glycosylation: a primer for histochemists and cell biologists.
Corfield A. (2017)
3 other articles