PDBe 1z1l

X-ray diffraction
1.7Å resolution

The Crystal Structure of the Phosphodiesterase 2A Catalytic Domain

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
cGMP-dependent 3',5'-cyclic phosphodiesterase Chain: A
Molecule details ›
Chain: A
Length: 345 amino acids
Theoretical weight: 40.31 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O00408 (Residues: 575-919; Coverage: 37%)
Gene name: PDE2A
Sequence domains: 3'5'-cyclic nucleotide phosphodiesterase
Structure domains: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: C2221
Unit cell:
a: 90.033Å b: 102.549Å c: 81.598Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.206 0.237
Expression system: Spodoptera frugiperda