PDBe 1y6n

X-ray diffraction
2.7Å resolution

Crystal structure of Epstein-Barr virus IL-10 mutant (A87I) complexed with the soluble IL-10R1 chain


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Viral interleukin-10 homolog Chain: L
Molecule details ›
Chain: L
Length: 145 amino acids
Theoretical weight: 17.44 KDa
Source organism: Human gammaherpesvirus 4
Expression system: Escherichia coli
  • Canonical: P03180 (Residues: 26-170; Coverage: 99%)
Gene name: BCRF1
Structure domains: Growth Hormone; Chain: A;
Interleukin-10 receptor subunit alpha Chain: R
Molecule details ›
Chain: R
Length: 214 amino acids
Theoretical weight: 24.51 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
  • Canonical: Q13651 (Residues: 22-235; Coverage: 38%)
Gene names: IL10R, IL10RA
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P3212
Unit cell:
a: 45.603Å b: 45.603Å c: 310.611Å
α: 90° β: 90° γ: 120°
R R work R free
0.211 0.206 0.271
Expression systems:
  • Escherichia coli
  • Drosophila melanogaster