PDBe 1xxd

X-ray diffraction
2.91Å resolution

Crystal Structure of the FXIa Catalytic Domain in Complex with mutated Ecotin


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Coagulation factor XIa light chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 238 amino acids
Theoretical weight: 26.83 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
  • Canonical: P03951 (Residues: 388-625; Coverage: 39%)
Gene name: F11
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Ecotin Chains: C, D
Molecule details ›
Chains: C, D
Length: 142 amino acids
Theoretical weight: 16.24 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli BL21
  • Canonical: P23827 (Residues: 21-162; Coverage: 100%)
Gene names: JW2197, b2209, eco, eti
Sequence domains: Ecotin
Structure domains: Immunoglobulin-like

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P212121
Unit cell:
a: 45.448Å b: 91.418Å c: 188.559Å
α: 90° β: 90° γ: 90°
R R work R free
0.23 0.23 0.282
Expression systems:
  • Komagataella pastoris
  • Escherichia coli BL21