› 1xt3

X-ray diffraction
2.4Å resolution

Structure Basis of Venom Citrate-Dependent Heparin Sulfate-Mediated Cell Surface Retention of Cobra Cardiotoxin A3

Released:
DOI: 10.2210/pdb1xt3/pdb
PDB entry 1xt3 coloured by chain, front view.
PDB entry 1xt3 coloured by chain, side view.
PDB entry 1xt3 coloured by chain, top view.
Source organism: Naja atra
Primary publication:
Structural basis of citrate-dependent and heparan sulfate-mediated cell surface retention of cobra cardiotoxin A3.
Lee SC, Guan HH, Wang CH, Huang WN, Tjong SC, Chen CJ, Wu WG
J Biol Chem 280 9567-77 (2005)
PMID: 15590643

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157993 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Cytotoxin 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 60 amino acids
Theoretical weight: 6.76 KDa
Source organism: Naja atra
UniProt:
  • Canonical: P60301 (Residues: 22-81; Coverage: 100%)
Structure domains: CD59

Ligands and Environments

Carbohydrate polymer : NEW Components: SGN, IDS
Carbohydrate polymer
1 bound ligand:
Ligand CIT 1 x CIT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL17B2
Spacegroup: C2221
Unit cell:
a: 43.903Å b: 59.447Å c: 98.62Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.242 0.227 0.25

Quick links

Citations

3 review citations

The structure of glycosaminoglycans and their interactions with proteins.
Gandhi et al. (2008)
2 more

8 mentions without citation

Sequence and structural features of carbohydrate binding in proteins and assessment of predictability using a neural network.
Malik et al. (2007)
7 more