› 1xf7

Solution NMR

High Resolution NMR Structure of the Wilms' Tumor Suppressor Protein (WT1) Finger 3

Released:
DOI: 10.2210/pdb1xf7/pdb
PDB entry 1xf7 coloured by chain, ensemble of 40 models, front view.
PDB entry 1xf7 coloured by chain, ensemble of 40 models, side view.
PDB entry 1xf7 coloured by chain, ensemble of 40 models, top view.
Source organism: Homo sapiens
Primary publication:
Why zinc fingers prefer zinc: ligand-field symmetry and the hidden thermodynamics of metal ion selectivity.
Lachenmann MJ, Ladbury JE, Dong J, Huang K, Carey P, Weiss MA
Biochemistry 43 13910-25 (2004)
PMID: 15518539

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148637 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Wilms tumor protein Chain: A
Molecule details ›
Chain: A
Length: 29 amino acids
Theoretical weight: 3.5 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P19544 (Residues: 381-409; Coverage: 7%)
Gene name: WT1
Sequence domains: Zinc finger, C2H2 type

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: DISTANCE GEOMETRY/SIMULATED ANNEALING FOLLOWED BY RESTRAINED MOLECULAR DYNAMICS
Expression system: Not provided

Quick links

Citations

4 review citations

Zinc metalloproteins as medicinal targets.
Anzellotti et al. (2008)
3 more