› 1x8s

X-ray diffraction
2.5Å resolution

Structure of the Par-6 PDZ domain with a Pals1 internal ligand

Released:
DOI: 10.2210/pdb1x8s/pdb
PDB entry 1x8s coloured by chain, front view.
PDB entry 1x8s coloured by chain, side view.
PDB entry 1x8s coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Internal recognition through PDZ domain plasticity in the Par-6-Pals1 complex.
Penkert RR, DiVittorio HM, Prehoda KE
Nat Struct Mol Biol 11 1122-7 (2004)
PMID: 15475968

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132171 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
LD29223p Chain: A
Molecule details ›
Chain: A
Length: 102 amino acids
Theoretical weight: 10.93 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O97111 (Residues: 156-255; Coverage: 29%)
Gene names: CG5884, DPar-6, DPar6, Dm-Par-6, Dm-Par6, DmPAR-6, DmPar-6, DmPar6, Dmel\CG5884, Dmel_CG5884, Dmpar6, PAR-6, PAR6, Par, Par-6, Par6, dPAR-6, dPar-6, dmPar-6, par, par-6, par6
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain
Pals1 peptide Chain: B
Molecule details ›
Chain: B
Length: 12 amino acids
Theoretical weight: 1.45 KDa
Source organism: Drosophila melanogaster
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: R3
Unit cell:
a: 63.122Å b: 63.122Å c: 99.276Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.217 0.216 0.254
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

15 review citations

Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density.
Feng et al. (2009)
14 more

7 mentions without citation

Plasticity of PDZ domains in ligand recognition and signaling.
Ivarsson Y. (2012)
6 more