PDBe 1x88

X-ray diffraction
1.8Å resolution

Human Eg5 motor domain bound to Mg-ADP and monastrol

Released:
Source organism: Homo sapiens
Entry authors: Maliga Z, Mitchison TJ

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kinesin-like protein KIF11 Chains: A, B
Molecule details ›
Chains: A, B
Length: 359 amino acids
Theoretical weight: 40.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P52732 (Residues: 10-368; Coverage: 34%)
Gene names: EG5, KIF11, KNSL1, TRIP5
Sequence domains: Kinesin motor domain
Structure domains: Kinesin motor domain

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P212121
Unit cell:
a: 69.706Å b: 79.648Å c: 159.451Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.203 0.225
Expression system: Escherichia coli BL21(DE3)