X-ray diffraction
2.3Å resolution

Crystal structure of tryptophan synthase alpha-subunit from Escherichia coli


Function and Biology Details

Reaction catalysed:
(1a) 1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate
Biochemical function:
Cellular component:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
Entry contents:
1 distinct polypeptide molecule
Tryptophan synthase alpha chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 268 amino acids
Theoretical weight: 28.75 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
  • Canonical: P0A877 (Residues: 1-268; Coverage: 100%)
Gene names: JW1252, b1260, trpA
Sequence domains: Tryptophan synthase alpha chain
Structure domains: Aldolase class I

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Spacegroup: C2
Unit cell:
a: 156.774Å b: 44.626Å c: 71.716Å
α: 90° β: 96.46° γ: 90°
R R work R free
0.185 0.185 0.248
Expression system: Escherichia coli