› 1wab

X-ray diffraction
1.7Å resolution

PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE

Released:
DOI: 10.2210/pdb1wab/pdb
PDB entry 1wab coloured by chain, front view.
PDB entry 1wab coloured by chain, side view.
PDB entry 1wab coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Brain acetylhydrolase that inactivates platelet-activating factor is a G-protein-like trimer.
Ho YS, Swenson L, Derewenda U, Serre L, Wei Y, Dauter Z, Hattori M, Adachi T, Aoki J, Arai H, Inoue K, Derewenda ZS
Nature 385 89-93 (1997)
PMID: 8985254

Function and Biology Details

Reaction catalysed: 
1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H(2)O = 1-alkyl-sn-glycero-3-phosphocholine + acetate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173350 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Platelet-activating factor acetylhydrolase IB subunit alpha1 Chain: A
Molecule details ›
Chain: A
Length: 232 amino acids
Theoretical weight: 25.9 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q29460 (Residues: 1-232; Coverage: 100%)
Gene names: PAFAH1B3, PAFAHG
Sequence domains: GDSL-like Lipase/Acylhydrolase family
Structure domains: SGNH hydrolase

Ligands and Environments

1 bound ligand:
Ligand ACT 1 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE BW7B
Spacegroup: P3121
Unit cell:
a: 81.26Å b: 81.26Å c: 72.6Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.195 0.195 not available

Quick links

Citations

32 review citations

The expanding superfamily of phospholipase A(2) enzymes: classification and characterization.
Six et al. (2000)
31 more

9 mentions without citation

Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention.
Dennis et al. (2011)
8 more