1w4r

X-ray diffraction
1.83Å resolution

Structure of a type II thymidine kinase with bound dTTP

Released:
Source organism: Homo sapiens
Primary publication:
Structure of a type II thymidine kinase with bound dTTP.
FEBS Lett. 579 1376-82 (2005)
PMID: 15733844

Function and Biology Details

Reaction catalysed:
ATP + thymidine = ADP + thymidine 5'-phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thymidine kinase, cytosolic Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 195 amino acids
Theoretical weight: 21.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04183 (Residues: 15-194; Coverage: 77%)
Gene name: TK1
Sequence domains: Thymidine kinase
Structure domains:

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: C2
Unit cell:
a: 157.496Å b: 122.92Å c: 115.274Å
α: 90° β: 130° γ: 90°
R-values:
R R work R free
0.16 0.159 0.189
Expression system: Escherichia coli